Regulation of miR106b cluster through the RB pathway: Mechanism and functional targets

The RB pathway plays a critical role in proliferation control that is commonly subverted in tumor development. However, restoration of RB pathway function can be elicited in many tumor cells by the inhibition of CDK4/6 activity that leads to dephosphorylation of RB and subsequent repression of E2F-m...

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Main Authors: Thangavel, Chellappagounder, Boopathi, Ettickan, Ertel, Adam, Lim, Meng, Addya, Sankar, Fortina, Paolo, Witkiewicz, Agnieszka K., Knudsen, Erik S.
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570523/
https://ncbi.nlm.nih.gov/pubmed/23255112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23029
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