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Unique Impact of RB Loss on Hepatic Proliferation: TUMORIGENIC STRESSES UNCOVER DISTINCT PATHWAYS OF CELL CYCLE CONTROL

The retinoblastoma (RB) tumor suppressor pathway is disrupted at high frequency in hepatocellular carcinoma. However, the mechanisms through which RB modulates physiological responses in the liver remain poorly defined. Despite the well established role of RB in cell cycle control, the deletion of R...

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Detalhes bibliográficos
Main Authors: Reed, Christopher A., Mayhew, Christopher N., McClendon, A. Kathleen, Knudsen, Erik S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801236/
https://ncbi.nlm.nih.gov/pubmed/19887370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.043380
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