High-Risk Human Papillomavirus E6 Protein Promotes Reprogramming of Fanconi Anemia Patient Cells through Repression of p53 but Does Not Allow for Sustained Growth of Induced Pluripotent Stem Cells

DNA repair plays a crucial role in embryonic and somatic stem cell biology and cell reprogramming. The Fanconi anemia (FA) pathway, which promotes error-free repair of DNA double-strand breaks, is required for somatic cell reprogramming to induced pluripotent stem cells (iPSC). Thus, cells from Fanc...

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Detalhes bibliográficos
Main Authors: Chlon, Timothy M., Hoskins, Elizabeth E., Mayhew, Christopher N., Wikenheiser-Brokamp, Kathryn A., Davies, Stella M., Mehta, Parinda, Myers, Kasiani C., Wells, James M., Wells, Susanne I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Transformation and Oncogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178785/
https://ncbi.nlm.nih.gov/pubmed/25031356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01533-14
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