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Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage
Pluripotent stem cells (PSCs) maintain a low mutation frequency compared with somatic cell types at least in part by preferentially utilizing error-free homologous recombination (HR) for DNA repair. Many endogenous metabolites cause DNA interstrand crosslinks, which are repaired by the Fanconi anemi...
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Publicado no: | Stem Cell Reports |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Elsevier
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4719133/ https://ncbi.nlm.nih.gov/pubmed/26771352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.12.001 |
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