Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro

Por Ozawa, Daisaku, Nomura, Ryo, Mangione, P. Patrizia, Hasegawa, Kazuhiro, Okoshi, Tadakazu, Porcari, Riccardo, Bellotti, Vittorio, Naiki, Hironobu
Publicado no Sci Rep (2016)

Lysozyme amyloid: evidence for the W64R variant by proteomics in the absence of the wild type protein

Por Moura, Alexandra, Nocerino, Paola, Gilbertson, Janet A., Rendell, Nigel B., Mangione, P. Patrizia, Verona, Guglielmo, Rowczenio, Dorota, Gillmore, Julian D., Taylor, Graham W., Bellotti, Vittorio, Canetti, Diana
Publicado no Amyloid (2020)

Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- and Long-Distance Conformational Changes

Por Corazza, Alessandra, Verona, Guglielmo, Waudby, Christopher A., Mangione, P. Patrizia, Bingham, Ryan, Uings, Iain, Canetti, Diana, Nocerino, Paola, Taylor, Graham W., Pepys, Mark B., Christodoulou, John, Bellotti, Vittorio
Publicado no J Med Chem (2019)

Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel

Por Verona, Guglielmo, Mangione, P. Patrizia, Raimondi, Sara, Giorgetti, Sofia, Faravelli, Giulia, Porcari, Riccardo, Corazza, Alessandra, Gillmore, Julian D., Hawkins, Philip N., Pepys, Mark B., Taylor, Graham W., Bellotti, Vittorio
Publicado no Sci Rep (2017)

Co-fibrillogenesis of Wild-type and D76N β(2)-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS

Por Natalello, Antonino, Mangione, P. Patrizia, Giorgetti, Sofia, Porcari, Riccardo, Marchese, Loredana, Zorzoli, Irene, Relini, Annalisa, Ami, Diletta, Faravelli, Giulia, Valli, Maurizia, Stoppini, Monica, Doglia, Silvia M., Bellotti, Vittorio, Raimondi, Sara
Publicado no J Biol Chem (2016)

Proteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis

Por Taylor, Graham W., Gilbertson, Janet A., Sayed, Rabya, Blanco, Angel, Rendell, Nigel B., Rowczenio, Dorota, Rezk, Tamer, Mangione, P. Patrizia, Canetti, Diana, Bass, Paul, Hawkins, Philip N., Gillmore, Julian D.
Publicado no Kidney Int Rep (2019)

Monitoring the Interaction between β(2)-Microglobulin and the Molecular Chaperone αB-crystallin by NMR and Mass Spectrometry: αB-CRYSTALLIN DISSOCIATES β(2)-MICROGLOBULIN OLIGOMERS...

Por Esposito, Gennaro, Garvey, Megan, Alverdi, Vera, Pettirossi, Fabio, Corazza, Alessandra, Fogolari, Federico, Polano, Maurizio, Mangione, P. Patrizia, Giorgetti, Sofia, Stoppini, Monica, Rekas, Agata, Bellotti, Vittorio, Heck, Albert J. R., Carver, John A.
Publicado em 2013

The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis

Por Rezk, Tamer, Gilbertson, Janet A, Mangione, P Patrizia, Rowczenio, Dorota, Rendell, Nigel B, Canetti, Diana, Lachmann, Helen J, Wechalekar, Ashutosh D, Bass, Paul, Hawkins, Philip N, Bellotti, Vittorio, Taylor, Graham W, Gillmore, Julian D
Publicado no J Pathol Clin Res (2019)

Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils

Por Raimondi, Sara, Mangione, P. Patrizia, Verona, Guglielmo, Canetti, Diana, Nocerino, Paola, Marchese, Loredana, Piccarducci, Rebecca, Mondani, Valentina, Faravelli, Giulia, Taylor, Graham W., Gillmore, Julian D., Corazza, Alessandra, Pepys, Mark B., Giorgetti, Sofia, Bellotti, Vittorio
Publicado no J Biol Chem (2020)

C. elegans expressing D76N β(2)-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis

Por Faravelli, Giulia, Raimondi, Sara, Marchese, Loredana, Partridge, Frederick A., Soria, Cristina, Mangione, P. Patrizia, Canetti, Diana, Perni, Michele, Aprile, Francesco A., Zorzoli, Irene, Di Schiavi, Elia, Lomas, David A., Bellotti, Vittorio, Sattelle, David B., Giorgetti, Sofia
Publicado no Sci Rep (2019)

Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β(2)-Microglobulin

Por Halabelian, Levon, Ricagno, Stefano, Giorgetti, Sofia, Santambrogio, Carlo, Barbiroli, Alberto, Pellegrino, Sara, Achour, Adnane, Grandori, Rita, Marchese, Loredana, Raimondi, Sara, Mangione, P. Patrizia, Esposito, Gennaro, Al-Shawi, Raya, Simons, J. Paul, Speck, Ivana, Stoppini, Monica, Bolognesi, Martino, Bellotti, Vittorio
Publicado em 2014

Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies

Por Mangione, P. Patrizia, Mazza, Giuseppe, Gilbertson, Janet A., Rendell, Nigel B., Canetti, Diana, Giorgetti, Sofia, Frenguelli, Luca, Curti, Marco, Rezk, Tamer, Raimondi, Sara, Pepys, Mark B., Hawkins, Philip N., Gillmore, Julian D., Taylor, Graham W., Pinzani, Massimo, Bellotti, Vittorio
Publicado no J Proteomics (2017)

Amyloid persistence in decellularized liver: biochemical and histopathological characterization

Por Mazza, Giuseppe, Simons, J. Paul, Al-Shawi, Raya, Ellmerich, Stephan, Urbani, Luca, Giorgetti, Sofia, Taylor, Graham W., Gilbertson, Janet A., Hall, Andrew R., Al-Akkad, Walid, Dhar, Dipok, Hawkins, Philip N., De Coppi, Paolo, Pinzani, Massimo, Bellotti, Vittorio, Mangione, P. Patrizia
Publicado no Amyloid (2016)

The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

Por Porcari, Riccardo, Proukakis, Christos, Waudby, Christopher A., Bolognesi, Benedetta, Mangione, P. Patrizia, Paton, Jack F. S., Mullin, Stephen, Cabrita, Lisa D., Penco, Amanda, Relini, Annalisa, Verona, Guglielmo, Vendruscolo, Michele, Stoppini, Monica, Tartaglia, Gian Gaetano, Camilloni, Carlo, Christodoulou, John, Schapira, Anthony H. V., Bellotti, Vittorio
Publicado no J Biol Chem (2015)

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

Por Marcoux, Julien, Mangione, P Patrizia, Porcari, Riccardo, Degiacomi, Matteo T, Verona, Guglielmo, Taylor, Graham W, Giorgetti, Sofia, Raimondi, Sara, Sanglier-Cianférani, Sarah, Benesch, Justin LP, Cecconi, Ciro, Naqvi, Mohsin M, Gillmore, Julian D, Hawkins, Philip N, Stoppini, Monica, Robinson, Carol V, Pepys, Mark B, Bellotti, Vittorio
Publicado no EMBO Mol Med (2015)

Plasminogen activation triggers transthyretin amyloidogenesis in vitro

Por Mangione, P. Patrizia, Verona, Guglielmo, Corazza, Alessandra, Marcoux, Julien, Canetti, Diana, Giorgetti, Sofia, Raimondi, Sara, Stoppini, Monica, Esposito, Marilena, Relini, Annalisa, Canale, Claudio, Valli, Maurizia, Marchese, Loredana, Faravelli, Giulia, Obici, Laura, Hawkins, Philip N., Taylor, Graham W., Gillmore, Julian D., Pepys, Mark B., Bellotti, Vittorio
Publicado no J Biol Chem (2018)

Bifunctional crosslinking ligands for transthyretin

Por Mangione, P. Patrizia, Deroo, Stéphanie, Ellmerich, Stephan, Bellotti, Vittorio, Kolstoe, Simon, Wood, Stephen P., Robinson, Carol V., Smith, Martin D., Tennent, Glenys A., Broadbridge, Robert J., Council, Claire E., Thurston, Joanne R., Steadman, Victoria A., Vong, Antonio K., Swain, Christopher J., Pepys, Mark B., Taylor, Graham W.
Publicado no Open Biol (2015)

Structure, Folding Dynamics, and Amyloidogenesis of D76N β(2)-Microglobulin: ROLES OF SHEAR FLOW, HYDROPHOBIC SURFACES, AND α-CRYSTALLIN

Por Mangione, P. Patrizia, Esposito, Gennaro, Relini, Annalisa, Raimondi, Sara, Porcari, Riccardo, Giorgetti, Sofia, Corazza, Alessandra, Fogolari, Federico, Penco, Amanda, Goto, Yuji, Lee, Young-Ho, Yagi, Hisashi, Cecconi, Ciro, Naqvi, Mohsin M., Gillmore, Julian D., Hawkins, Philip N., Chiti, Fabrizio, Rolandi, Ranieri, Taylor, Graham W., Pepys, Mark B., Stoppini, Monica, Bellotti, Vittorio
Publicado em 2013

Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis

Por Mangione, P. Patrizia, Porcari, Riccardo, Gillmore, Julian D., Pucci, Piero, Monti, Maria, Porcari, Mattia, Giorgetti, Sofia, Marchese, Loredana, Raimondi, Sara, Serpell, Louise C., Chen, Wenjie, Relini, Annalisa, Marcoux, Julien, Clatworthy, Innes R., Taylor, Graham W., Tennent, Glenys A., Robinson, Carol V., Hawkins, Philip N., Stoppini, Monica, Wood, Stephen P., Pepys, Mark B., Bellotti, Vittorio
Publicado em 2014

A specific nanobody prevents amyloidogenesis of D76N β(2)-microglobulin in vitro and modifies its tissue distribution in vivo

Por Raimondi, Sara, Porcari, Riccardo, Mangione, P. Patrizia, Verona, Guglielmo, Marcoux, Julien, Giorgetti, Sofia, Taylor, Graham W., Ellmerich, Stephan, Ballico, Maurizio, Zanini, Stefano, Pardon, Els, Al-Shawi, Raya, Simons, J. Paul, Corazza, Alessandra, Fogolari, Federico, Leri, Manuela, Stefani, Massimo, Bucciantini, Monica, Gillmore, Julian D., Hawkins, Philip N., Valli, Maurizia, Stoppini, Monica, Robinson, Carol V., Steyaert, Jan, Esposito, Gennaro, Bellotti, Vittorio
Publicado no Sci Rep (2017)