Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- and Long-Distance Conformational Changes

[Image: see text] The wild type protein, transthyretin (TTR), and over 120 genetic TTR variants are amyloidogenic and cause, respectively, sporadic and hereditary systemic TTR amyloidosis. The homotetrameric TTR contains two identical thyroxine binding pockets, occupation of which by specific ligand...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Corazza, Alessandra, Verona, Guglielmo, Waudby, Christopher A., Mangione, P. Patrizia, Bingham, Ryan, Uings, Iain, Canetti, Diana, Nocerino, Paola, Taylor, Graham W., Pepys, Mark B., Christodoulou, John, Bellotti, Vittorio
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863598/
https://ncbi.nlm.nih.gov/pubmed/31393717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01037
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