Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils

Systemic amyloidosis caused by extracellular deposition of insoluble fibrils derived from the pathological aggregation of circulating proteins, such as transthyretin, is a severe and usually fatal condition. Elucidation of the molecular pathogenic mechanism of the disease and discovery of effective...

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Publié dans:J Biol Chem
Auteurs principaux: Raimondi, Sara, Mangione, P. Patrizia, Verona, Guglielmo, Canetti, Diana, Nocerino, Paola, Marchese, Loredana, Piccarducci, Rebecca, Mondani, Valentina, Faravelli, Giulia, Taylor, Graham W., Gillmore, Julian D., Corazza, Alessandra, Pepys, Mark B., Giorgetti, Sofia, Bellotti, Vittorio
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2020
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450123/
https://ncbi.nlm.nih.gov/pubmed/32571879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014026
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