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A specific nanobody prevents amyloidogenesis of D76N β(2)-microglobulin in vitro and modifies its tissue distribution in vivo
Systemic amyloidosis is caused by misfolding and aggregation of globular proteins in vivo for which effective treatments are urgently needed. Inhibition of protein self-aggregation represents an attractive therapeutic strategy. Studies on the amyloidogenic variant of β(2)-microglobulin, D76N, causin...
Shranjeno v:
| izdano v: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5399440/ https://ncbi.nlm.nih.gov/pubmed/28429761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46711 |
| Oznake: |
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