Structure, Folding Dynamics, and Amyloidogenesis of D76N β(2)-Microglobulin: ROLES OF SHEAR FLOW, HYDROPHOBIC SURFACES, AND α-CRYSTALLIN

Systemic amyloidosis is a fatal disease caused by misfolding of native globular proteins, which then aggregate extracellularly as insoluble fibrils, damaging the structure and function of affected organs. The formation of amyloid fibrils in vivo is poorly understood. We recently identified the first...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Mangione, P. Patrizia, Esposito, Gennaro, Relini, Annalisa, Raimondi, Sara, Porcari, Riccardo, Giorgetti, Sofia, Corazza, Alessandra, Fogolari, Federico, Penco, Amanda, Goto, Yuji, Lee, Young-Ho, Yagi, Hisashi, Cecconi, Ciro, Naqvi, Mohsin M., Gillmore, Julian D., Hawkins, Philip N., Chiti, Fabrizio, Rolandi, Ranieri, Taylor, Graham W., Pepys, Mark B., Stoppini, Monica, Bellotti, Vittorio
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2013
Pynciau:
Molecular Bases of Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829406/
https://ncbi.nlm.nih.gov/pubmed/24014031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.498857
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