Structure, Folding Dynamics, and Amyloidogenesis of D76N β(2)-Microglobulin: ROLES OF SHEAR FLOW, HYDROPHOBIC SURFACES, AND α-CRYSTALLIN

Systemic amyloidosis is a fatal disease caused by misfolding of native globular proteins, which then aggregate extracellularly as insoluble fibrils, damaging the structure and function of affected organs. The formation of amyloid fibrils in vivo is poorly understood. We recently identified the first...

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Hlavní autoři: Mangione, P. Patrizia, Esposito, Gennaro, Relini, Annalisa, Raimondi, Sara, Porcari, Riccardo, Giorgetti, Sofia, Corazza, Alessandra, Fogolari, Federico, Penco, Amanda, Goto, Yuji, Lee, Young-Ho, Yagi, Hisashi, Cecconi, Ciro, Naqvi, Mohsin M., Gillmore, Julian D., Hawkins, Philip N., Chiti, Fabrizio, Rolandi, Ranieri, Taylor, Graham W., Pepys, Mark B., Stoppini, Monica, Bellotti, Vittorio
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829406/
https://ncbi.nlm.nih.gov/pubmed/24014031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.498857
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