Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant

Por Bonì, Francesco, Milani, Mario, Porcari, Riccardo, Barbiroli, Alberto, Ricagno, Stefano, de Rosa, Matteo
Publicado no Sci Rep (2016)

Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro

Por Ozawa, Daisaku, Nomura, Ryo, Mangione, P. Patrizia, Hasegawa, Kazuhiro, Okoshi, Tadakazu, Porcari, Riccardo, Bellotti, Vittorio, Naiki, Hironobu
Publicado no Sci Rep (2016)

C. elegans Expressing Human β(2)-Microglobulin: A Novel Model for Studying the Relationship between the Molecular Assembly and the Toxic Phenotype

Por Diomede, Luisa, Soria, Cristina, Romeo, Margherita, Giorgetti, Sofia, Marchese, Loredana, Mangione, Patrizia Palma, Porcari, Riccardo, Zorzoli, Irene, Salmona, Mario, Bellotti, Vittorio, Stoppini, Monica
Publicado em 2012

Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability

Por Camilloni, Carlo, Sala, Benedetta Maria, Sormanni, Pietro, Porcari, Riccardo, Corazza, Alessandra, De Rosa, Matteo, Zanini, Stefano, Barbiroli, Alberto, Esposito, Gennaro, Bolognesi, Martino, Bellotti, Vittorio, Vendruscolo, Michele, Ricagno, Stefano
Publicado no Sci Rep (2016)

Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel

Por Verona, Guglielmo, Mangione, P. Patrizia, Raimondi, Sara, Giorgetti, Sofia, Faravelli, Giulia, Porcari, Riccardo, Corazza, Alessandra, Gillmore, Julian D., Hawkins, Philip N., Pepys, Mark B., Taylor, Graham W., Bellotti, Vittorio
Publicado no Sci Rep (2017)

Co-fibrillogenesis of Wild-type and D76N β(2)-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS

Por Natalello, Antonino, Mangione, P. Patrizia, Giorgetti, Sofia, Porcari, Riccardo, Marchese, Loredana, Zorzoli, Irene, Relini, Annalisa, Ami, Diletta, Faravelli, Giulia, Valli, Maurizia, Stoppini, Monica, Doglia, Silvia M., Bellotti, Vittorio, Raimondi, Sara
Publicado no J Biol Chem (2016)

Effect of Tetracyclines on the Dynamics of Formation and Destructuration of β2-Microglobulin Amyloid Fibrils

Por Giorgetti, Sofia, Raimondi, Sara, Pagano, Katiuscia, Relini, Annalisa, Bucciantini, Monica, Corazza, Alessandra, Fogolari, Federico, Codutti, Luca, Salmona, Mario, Mangione, Palma, Colombo, Lino, De Luigi, Ada, Porcari, Riccardo, Gliozzi, Alessandra, Stefani, Massimo, Esposito, Gennaro, Bellotti, Vittorio, Stoppini, Monica
Publicado em 2011

Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology

Por Izco, María, Blesa, Javier, Schleef, Martin, Schmeer, Marco, Porcari, Riccardo, Al-Shawi, Raya, Ellmerich, Stephan, de Toro, María, Gardiner, Chris, Seow, Yiqi, Reinares-Sebastian, Alejandro, Forcen, Raquel, Simons, J. Paul, Bellotti, Vittorio, Cooper, J. Mark, Alvarez-Erviti, Lydia
Publicado no Mol Ther (2019)

The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

Por Porcari, Riccardo, Proukakis, Christos, Waudby, Christopher A., Bolognesi, Benedetta, Mangione, P. Patrizia, Paton, Jack F. S., Mullin, Stephen, Cabrita, Lisa D., Penco, Amanda, Relini, Annalisa, Verona, Guglielmo, Vendruscolo, Michele, Stoppini, Monica, Tartaglia, Gian Gaetano, Camilloni, Carlo, Christodoulou, John, Schapira, Anthony H. V., Bellotti, Vittorio
Publicado no J Biol Chem (2015)

Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity

Por Le Marchand, Tanguy, de Rosa, Matteo, Salvi, Nicola, Sala, Benedetta Maria, Andreas, Loren B., Barbet-Massin, Emeline, Sormanni, Pietro, Barbiroli, Alberto, Porcari, Riccardo, Sousa Mota, Cristiano, de Sanctis, Daniele, Bolognesi, Martino, Emsley, Lyndon, Bellotti, Vittorio, Blackledge, Martin, Camilloni, Carlo, Pintacuda, Guido, Ricagno, Stefano
Publicado no Nat Commun (2018)

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

Por Marcoux, Julien, Mangione, P Patrizia, Porcari, Riccardo, Degiacomi, Matteo T, Verona, Guglielmo, Taylor, Graham W, Giorgetti, Sofia, Raimondi, Sara, Sanglier-Cianférani, Sarah, Benesch, Justin LP, Cecconi, Ciro, Naqvi, Mohsin M, Gillmore, Julian D, Hawkins, Philip N, Stoppini, Monica, Robinson, Carol V, Pepys, Mark B, Bellotti, Vittorio
Publicado no EMBO Mol Med (2015)

Structure, Folding Dynamics, and Amyloidogenesis of D76N β(2)-Microglobulin: ROLES OF SHEAR FLOW, HYDROPHOBIC SURFACES, AND α-CRYSTALLIN

Por Mangione, P. Patrizia, Esposito, Gennaro, Relini, Annalisa, Raimondi, Sara, Porcari, Riccardo, Giorgetti, Sofia, Corazza, Alessandra, Fogolari, Federico, Penco, Amanda, Goto, Yuji, Lee, Young-Ho, Yagi, Hisashi, Cecconi, Ciro, Naqvi, Mohsin M., Gillmore, Julian D., Hawkins, Philip N., Chiti, Fabrizio, Rolandi, Ranieri, Taylor, Graham W., Pepys, Mark B., Stoppini, Monica, Bellotti, Vittorio
Publicado em 2013

Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis

Por Mangione, P. Patrizia, Porcari, Riccardo, Gillmore, Julian D., Pucci, Piero, Monti, Maria, Porcari, Mattia, Giorgetti, Sofia, Marchese, Loredana, Raimondi, Sara, Serpell, Louise C., Chen, Wenjie, Relini, Annalisa, Marcoux, Julien, Clatworthy, Innes R., Taylor, Graham W., Tennent, Glenys A., Robinson, Carol V., Hawkins, Philip N., Stoppini, Monica, Wood, Stephen P., Pepys, Mark B., Bellotti, Vittorio
Publicado em 2014

A specific nanobody prevents amyloidogenesis of D76N β(2)-microglobulin in vitro and modifies its tissue distribution in vivo

Por Raimondi, Sara, Porcari, Riccardo, Mangione, P. Patrizia, Verona, Guglielmo, Marcoux, Julien, Giorgetti, Sofia, Taylor, Graham W., Ellmerich, Stephan, Ballico, Maurizio, Zanini, Stefano, Pardon, Els, Al-Shawi, Raya, Simons, J. Paul, Corazza, Alessandra, Fogolari, Federico, Leri, Manuela, Stefani, Massimo, Bucciantini, Monica, Gillmore, Julian D., Hawkins, Philip N., Valli, Maurizia, Stoppini, Monica, Robinson, Carol V., Steyaert, Jan, Esposito, Gennaro, Bellotti, Vittorio
Publicado no Sci Rep (2017)

D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile

Por Valleix, Sophie, Verona, Guglielmo, Jourde-Chiche, Noémie, Nédelec, Brigitte, Mangione, P. Patrizia, Bridoux, Frank, Mangé, Alain, Dogan, Ahmet, Goujon, Jean-Michel, Lhomme, Marie, Dauteuille, Carolane, Chabert, Michèle, Porcari, Riccardo, Waudby, Christopher A., Relini, Annalisa, Talmud, Philippa J., Kovrov, Oleg, Olivecrona, Gunilla, Stoppini, Monica, Christodoulou, John, Hawkins, Philip N., Grateau, Gilles, Delpech, Marc, Kontush, Anatol, Gillmore, Julian D., Kalopissis, Athina D., Bellotti, Vittorio
Publicado no Nat Commun (2016)