Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity

Spontaneous aggregation of folded and soluble native proteins in vivo is still a poorly understood process. A prototypic example is the D76N mutant of beta-2 microglobulin (β2m) that displays an aggressive aggregation propensity. Here we investigate the dynamics of β2m by X-ray crystallography, soli...

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Publicat a:Nat Commun
Autors principals: Le Marchand, Tanguy, de Rosa, Matteo, Salvi, Nicola, Sala, Benedetta Maria, Andreas, Loren B., Barbet-Massin, Emeline, Sormanni, Pietro, Barbiroli, Alberto, Porcari, Riccardo, Sousa Mota, Cristiano, de Sanctis, Daniele, Bolognesi, Martino, Emsley, Lyndon, Bellotti, Vittorio, Blackledge, Martin, Camilloni, Carlo, Pintacuda, Guido, Ricagno, Stefano
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916882/
https://ncbi.nlm.nih.gov/pubmed/29695721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04078-y
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