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DE-loop mutations affect β2 microglobulin stability, oligomerization, and the low-pH unfolded form
β2 microglobulin (β2m) is the light chain of class-I major histocompatibility complex (MHC-I). Its accumulation in the blood of patients affected by kidney failure leads to amyloid deposition around skeletal joints and bones, a severe condition known as Dialysis Related Amyloidosis (DRA). In an effo...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2974830/ https://ncbi.nlm.nih.gov/pubmed/20506535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.419 |
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