Wild Type Beta-2 Microglobulin and DE Loop Mutants Display a Common Fibrillar Architecture

Beta-2 microglobulin (β2m) is the protein responsible for a pathologic condition known as dialysis related amyloidosis. In recent years an important role has been assigned to the peptide loop linking strands D and E (DE loop) in determining β2m stability and amyloid propensity. Several mutants of th...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Natalello, Antonino, Relini, Annalisa, Penco, Amanda, Halabelian, Levon, Bolognesi, Martino, Doglia, Silvia Maria, Ricagno, Stefano
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372401/
https://ncbi.nlm.nih.gov/pubmed/25803608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122449
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