Structure, Stability, and Aggregation of β-2 Microglobulin Mutants: Insights from a Fourier Transform Infrared Study in Solution and in the Crystalline State

β-2 microglobulin (β2m) is an amyloidogenic protein involved in dialysis-related amyloidosis. We report here the study of the structural properties of the protein in solution and in the form of single crystals by Fourier transform infrared (FTIR) spectroscopy and microspectroscopy. The investigation...

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Bibliografske podrobnosti
Main Authors: Ami, Diletta, Ricagno, Stefano, Bolognesi, Martino, Bellotti, Vittorio, Doglia, Silvia Maria, Natalello, Antonino
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2012
Teme:
Spectroscopy, Imaging, and Other Techniques
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318121/
https://ncbi.nlm.nih.gov/pubmed/22500768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.02.045
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