Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity

Spontaneous aggregation of folded and soluble native proteins in vivo is still a poorly understood process. A prototypic example is the D76N mutant of beta-2 microglobulin (β2m) that displays an aggressive aggregation propensity. Here we investigate the dynamics of β2m by X-ray crystallography, soli...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Le Marchand, Tanguy, de Rosa, Matteo, Salvi, Nicola, Sala, Benedetta Maria, Andreas, Loren B., Barbet-Massin, Emeline, Sormanni, Pietro, Barbiroli, Alberto, Porcari, Riccardo, Sousa Mota, Cristiano, de Sanctis, Daniele, Bolognesi, Martino, Emsley, Lyndon, Bellotti, Vittorio, Blackledge, Martin, Camilloni, Carlo, Pintacuda, Guido, Ricagno, Stefano
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916882/
https://ncbi.nlm.nih.gov/pubmed/29695721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04078-y
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk