Effect of Tetracyclines on the Dynamics of Formation and Destructuration of β2-Microglobulin Amyloid Fibrils

The discovery of methods suitable for the conversion in vitro of native proteins into amyloid fibrils has shed light on the molecular basis of amyloidosis and has provided fundamental tools for drug discovery. We have studied the capacity of a small library of tetracycline analogues to modulate the...

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Detalhes bibliográficos
Main Authors: Giorgetti, Sofia, Raimondi, Sara, Pagano, Katiuscia, Relini, Annalisa, Bucciantini, Monica, Corazza, Alessandra, Fogolari, Federico, Codutti, Luca, Salmona, Mario, Mangione, Palma, Colombo, Lino, De Luigi, Ada, Porcari, Riccardo, Gliozzi, Alessandra, Stefani, Massimo, Esposito, Gennaro, Bellotti, Vittorio, Stoppini, Monica
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023509/
https://ncbi.nlm.nih.gov/pubmed/21068391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.178376
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