C. elegans expressing D76N β(2)-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis

The availability of a genetic model organism with which to study key molecular events underlying amyloidogenesis is crucial for elucidating the mechanism of the disease and the exploration of new therapeutic avenues. The natural human variant of β(2)-microglobulin (D76N β(2)-m) is associated with a...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Faravelli, Giulia, Raimondi, Sara, Marchese, Loredana, Partridge, Frederick A., Soria, Cristina, Mangione, P. Patrizia, Canetti, Diana, Perni, Michele, Aprile, Francesco A., Zorzoli, Irene, Di Schiavi, Elia, Lomas, David A., Bellotti, Vittorio, Sattelle, David B., Giorgetti, Sofia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934621/
https://ncbi.nlm.nih.gov/pubmed/31882874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56498-5
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