Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors

Autor Hart, Amy C., Schroeder, Gretchen M., Wan, Honghe, Grebinski, James, Inghrim, Jennifer, Kempson, James, Guo, Junqing, Pitts, William J., Tokarski, John S., Sack, John S., Khan, Javed A., Lippy, Jonathan, Lorenzi, Matthew V., You, Dan, McDevitt, Theresa, Vuppugalla, Ragini, Zhang, Yueping, Lombardo, Louis J., Trainor, George L., Purandare, Ashok V.
Vydáno v ACS Med Chem Lett (2015)

Discovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents

Autor Zhang, Yong, Zhao, Yufen, Tebben, Andrew J., Sheriff, Steven, Ruzanov, Max, Fereshteh, Mark P., Fan, Yi, Lippy, Jonathan, Swanson, Jesse, Ho, Ching-Ping, Wautlet, Barri S., Rose, Anne, Parrish, Karen, Yang, Zheng, Donnell, Andrew F., Zhang, Liping, Fink, Brian E., Vite, Gregory D., Augustine-Rauch, Karen, Fargnoli, Joseph, Borzilleri, Robert M.
Vydáno v ACS Med Chem Lett (2018)

Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis

Autor Spergel, Steven H., Mertzman, Michael E., Kempson, James, Guo, Junqing, Stachura, Sylwia, Haque, Lauren, Lippy, Jonathan S., Zhang, Rosemary F., Galella, Michael, Pitt, Sidney, Shen, Guoxiang, Fura, Aberra, Gillooly, Kathleen, McIntyre, Kim W., Tang, Vicky, Tokarski, John, Sack, John S., Khan, Javed, Carter, Percy H., Barrish, Joel C., Nadler, Steven G., Salter-Cid, Luisa M., Schieven, Gary L., Wrobleski, Stephen T., Pitts, William J.
Vydáno v ACS Med Chem Lett (2019)

Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent

Autor Velaparthi, Upender, Darne, Chetan Padmakar, Warrier, Jayakumar, Liu, Peiying, Rahaman, Hasibur, Augustine-Rauch, Karen, Parrish, Karen, Yang, Zheng, Swanson, Jesse, Brown, Jennifer, Dhar, Gopal, Anandam, Aravind, Holenarsipur, Vinay K., Palanisamy, Kamalavenkatesh, Wautlet, Barri S., Fereshteh, Mark P., Lippy, Jonathan, Tebben, Andrew J., Sheriff, Steven, Ruzanov, Max, Yan, Chunhong, Gupta, Anuradha, Gupta, Arun Kumar, Vetrichelvan, Muthalagu, Mathur, Arvind, Gelman, Marina, Singh, Rajinder, Kinsella, Todd, Murtaza, Anwar, Fargnoli, Joseph, Vite, Gregory, Borzilleri, Robert M.
Vydáno v ACS Med Chem Lett (2020)

Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms

Autor Wan, Honghe, Schroeder, Gretchen M., Hart, Amy C., Inghrim, Jennifer, Grebinski, James, Tokarski, John S., Lorenzi, Matthew V., You, Dan, Mcdevitt, Theresa, Penhallow, Becky, Vuppugalla, Ragini, Zhang, Yueping, Gu, Xiaomei, Iyer, Ramaswamy, Lombardo, Louis J., Trainor, George L., Ruepp, Stefan, Lippy, Jonathan, Blat, Yuval, Sack, John S., Khan, Javed A., Stefanski, Kevin, Sleczka, Bogdan, Mathur, Arvind, Sun, Jung-Hui, Wong, Michael K., Wu, Dauh-Rurng, Li, Peng, Gupta, Anuradha, Arunachalam, P. N., Pragalathan, Bala, Narayanan, Sankara, K.C., Nanjundaswamy, Kuppusamy, Prakasam, Purandare, Ashok V.
Vydáno v ACS Med Chem Lett (2015)

Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain

Autor Kostich, Walter, Hamman, Brian D., Li, Yu-Wen, Naidu, Sreenivasulu, Dandapani, Kumaran, Feng, Jianlin, Easton, Amy, Bourin, Clotilde, Baker, Kevin, Allen, Jason, Savelieva, Katerina, Louis, Justin V., Dokania, Manoj, Elavazhagan, Saravanan, Vattikundala, Pradeep, Sharma, Vivek, Das, Manish Lal, Shankar, Ganesh, Kumar, Anoop, Holenarsipur, Vinay K., Gulianello, Michael, Molski, Ted, Brown, Jeffrey M., Lewis, Martin, Huang, Yanling, Lu, Yifeng, Pieschl, Rick, O’Malley, Kevin, Lippy, Jonathan, Nouraldeen, Amr, Lanthorn, Thomas H., Ye, Guilan, Wilson, Alan, Balakrishnan, Anand, Denton, Rex, Grace, James E., Lentz, Kimberley A., Santone, Kenneth S., Bi, Yingzhi, Main, Alan, Swaffield, Jon, Carson, Ken, Mandlekar, Sandhya, Vikramadithyan, Reeba K., Nara, Susheel J., Dzierba, Carolyn, Bronson, Joanne, Macor, John E., Zaczek, Robert, Westphal, Ryan, Kiss, Laszlo, Bristow, Linda, Conway, Charles M., Zambrowicz, Brian, Albright, Charles F.
Vydáno v J Pharmacol Exp Ther (2016)