Discovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents

[Image: see text] The multifunctional cytokine TGFβ plays a central role in regulating antitumor immunity. It has been postulated that inhibition of TGFβ signaling in concert with checkpoint blockade will provide improved and durable immune response against tumors. Herein, we describe a novel series...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Zhang, Yong, Zhao, Yufen, Tebben, Andrew J., Sheriff, Steven, Ruzanov, Max, Fereshteh, Mark P., Fan, Yi, Lippy, Jonathan, Swanson, Jesse, Ho, Ching-Ping, Wautlet, Barri S., Rose, Anne, Parrish, Karen, Yang, Zheng, Donnell, Andrew F., Zhang, Liping, Fink, Brian E., Vite, Gregory D., Augustine-Rauch, Karen, Fargnoli, Joseph, Borzilleri, Robert M.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2018
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231184/
https://ncbi.nlm.nih.gov/pubmed/30429955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00357
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