Discovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents

[Image: see text] The multifunctional cytokine TGFβ plays a central role in regulating antitumor immunity. It has been postulated that inhibition of TGFβ signaling in concert with checkpoint blockade will provide improved and durable immune response against tumors. Herein, we describe a novel series...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Med Chem Lett
Prif Awduron: Zhang, Yong, Zhao, Yufen, Tebben, Andrew J., Sheriff, Steven, Ruzanov, Max, Fereshteh, Mark P., Fan, Yi, Lippy, Jonathan, Swanson, Jesse, Ho, Ching-Ping, Wautlet, Barri S., Rose, Anne, Parrish, Karen, Yang, Zheng, Donnell, Andrew F., Zhang, Liping, Fink, Brian E., Vite, Gregory D., Augustine-Rauch, Karen, Fargnoli, Joseph, Borzilleri, Robert M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2018
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231184/
https://ncbi.nlm.nih.gov/pubmed/30429955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00357
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