Discovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents

[Image: see text] The multifunctional cytokine TGFβ plays a central role in regulating antitumor immunity. It has been postulated that inhibition of TGFβ signaling in concert with checkpoint blockade will provide improved and durable immune response against tumors. Herein, we describe a novel series...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Zhang, Yong, Zhao, Yufen, Tebben, Andrew J., Sheriff, Steven, Ruzanov, Max, Fereshteh, Mark P., Fan, Yi, Lippy, Jonathan, Swanson, Jesse, Ho, Ching-Ping, Wautlet, Barri S., Rose, Anne, Parrish, Karen, Yang, Zheng, Donnell, Andrew F., Zhang, Liping, Fink, Brian E., Vite, Gregory D., Augustine-Rauch, Karen, Fargnoli, Joseph, Borzilleri, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231184/
https://ncbi.nlm.nih.gov/pubmed/30429955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00357
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados