Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

door Pham, Christine T. N., Ley, Timothy J.
Gepubliceerd in 1999

Neutrophil Elastase Is Important for PML-Retinoic Acid Receptor α Activities in Early Myeloid Cells

door Lane, Andrew A., Ley, Timothy J.
Gepubliceerd in 2005

PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice

door Welch, John S., Yuan, Wenlin, Ley, Timothy J.
Gepubliceerd in 2011

YB-1 Is Important for Late-Stage Embryonic Development, Optimal Cellular Stress Responses, and the Prevention of Premature Senescence

door Lu, Zhi Hong, Books, Jason T., Ley, Timothy J.
Gepubliceerd in 2005

Cold Shock Domain Family Members YB-1 and MSY4 Share Essential Functions during Murine Embryogenesis

door Lu, Zhi Hong, Books, Jason T., Ley, Timothy J.
Gepubliceerd in 2006

Genomic Landscapes and Clonality of De Novo AML

door Miller, Christopher A., Wilson, Richard K., Ley, Timothy J.
Gepubliceerd in N Engl J Med (2013)

Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice

door Welch, John S., Klco, Jeffery M., Varghese, Nobish, Nagarajan, Rakesh, Ley, Timothy J.
Gepubliceerd in 2011

Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro

door Sarkaria, Shawn M., Christopher, Matthew J., Klco, Jeffery M., Ley, Timothy J.
Gepubliceerd in Leukemia (2014)

Granzyme B is not required for regulatory T cell–mediated suppression of graft-versus-host disease

door Cai, Sheng F., Cao, Xuefang, Hassan, Anjum, Fehniger, Todd A., Ley, Timothy J.
Gepubliceerd in 2010

Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice

door Zimonjic, Drazen B., Pollock, Jessica L., Westervelt, Peter, Popescu, Nicholas C., Ley, Timothy J.
Gepubliceerd in 2000

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK

door Thomas, Dori A., Scorrano, Luca, Putcha, Girish V., Korsmeyer, Stanley J., Ley, Timothy J.
Gepubliceerd in 2001

Granzymes and Caspase 3 Play Important Roles in Control of Gammaherpesvirus Latency

door Loh, Joy, Thomas, Dori A., Revell, Paula A., Ley, Timothy J., Virgin, Herbert W.
Gepubliceerd in 2004

DNMT3A(R882)-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3A(R882C) OCI-AML3 leukemia cell line

door Chen, David, Christopher, Matthew, Helton, Nichole M., Ferguson, Ian, Ley, Timothy J., Spencer, David H.
Gepubliceerd in Blood Cancer J (2018)

Long-range disruption of gene expression by a selectable marker cassette

door Pham, Christine T. N., MacIvor, Debra M., Hug, Bruce A., Heusel, Jonathan W., Ley, Timothy J.
Gepubliceerd in 1996

Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia

door Chang, Li Wei, Payton, Jacqueline E, Yuan, Wenlin, Ley, Timothy J, Nagarajan, Rakesh, Stormo, Gary D
Gepubliceerd in 2008

A bcr-3 isoform of RARα-PML potentiates the development of PML-RARα-driven acute promyelocytic leukemia

door Pollock, Jessica L., Westervelt, Peter, Kurichety, Arun K., Pelicci, Pier Giuseppe, Grisolano, Jay L., Ley, Timothy J.
Gepubliceerd in 1999

Expression of a bcr-1 isoform of RARα-PML does not affect the penetrance of acute promyelocytic leukemia or the acquisition of an interstitial deletion on mouse chromosome 2

door Walter, Matthew J., Ries, Rhonda E., Armstrong, Jon R., Park, John S., Mardis, Elaine R., Ley, Timothy J.
Gepubliceerd in 2007

POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature

door Fortier, Julie M., Payton, Jacqueline E., Cahan, Patrick, Ley, Timothy J., Walter, Matthew J., Graubert, Timothy A.
Gepubliceerd in 2010

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia

door Xiang, Zhifu, Luo, Hui, Payton, Jacqueline E., Cain, Jennifer, Ley, Timothy J., Opferman, Joseph T., Tomasson, Michael H.
Gepubliceerd in 2010

A protease-resistant PML-RARα has increased leukemogenic potential in a murine model of acute promyelocytic leukemia

door Uy, Geoffrey L., Lane, Andrew A., Welch, John S., Grieselhuber, Nicole R., Payton, Jacqueline E., Ley, Timothy J.
Gepubliceerd in 2010