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Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

Dipeptidyl peptidase I (DPPI) is a lysosomal cysteine protease that has been implicated in the processing of granzymes, which are neutral serine proteases exclusively expressed in the granules of activated cytotoxic lymphocytes. In this report, we show that cytotoxic lymphocytes derived from DPPI−/−...

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Bibliografiske detaljer
Main Authors: Pham, Christine T. N., Ley, Timothy J.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC17567/
https://ncbi.nlm.nih.gov/pubmed/10411926
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