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Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

Dipeptidyl peptidase I (DPPI) is a lysosomal cysteine protease that has been implicated in the processing of granzymes, which are neutral serine proteases exclusively expressed in the granules of activated cytotoxic lymphocytes. In this report, we show that cytotoxic lymphocytes derived from DPPI−/−...

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Bibliografske podrobnosti
Main Authors: Pham, Christine T. N., Ley, Timothy J.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC17567/
https://ncbi.nlm.nih.gov/pubmed/10411926
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