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Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo
Dipeptidyl peptidase I (DPPI) is a lysosomal cysteine protease that has been implicated in the processing of granzymes, which are neutral serine proteases exclusively expressed in the granules of activated cytotoxic lymphocytes. In this report, we show that cytotoxic lymphocytes derived from DPPI−/−...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The National Academy of Sciences
1999
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC17567/ https://ncbi.nlm.nih.gov/pubmed/10411926 |
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