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Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK
Granzyme B (GzmB) is a serine protease that is used by activated cytotoxic T lymphocytes to induce target cell apoptosis. Although GzmB directly cleaves the Bcl2 family member BID on target cell entry, Bid-deficient (and Bax, Bak doubly deficient) cells are susceptible to GzmB-induced death, even th...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The National Academy of Sciences
2001
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC64970/ https://ncbi.nlm.nih.gov/pubmed/11752447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.261581498 |
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