Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK
Granzyme B (GzmB) is a serine protease that is used by activated cytotoxic T lymphocytes to induce target cell apoptosis. Although GzmB directly cleaves the Bcl2 family member BID on target cell entry, Bid-deficient (and Bax, Bak doubly deficient) cells are susceptible to GzmB-induced death, even th...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2001
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC64970/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11752447/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.261581498 |
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