Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK

Granzyme B (GzmB) is a serine protease that is used by activated cytotoxic T lymphocytes to induce target cell apoptosis. Although GzmB directly cleaves the Bcl2 family member BID on target cell entry, Bid-deficient (and Bax, Bak doubly deficient) cells are susceptible to GzmB-induced death, even th...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Thomas, Dori A., Scorrano, Luca, Putcha, Girish V., Korsmeyer, Stanley J., Ley, Timothy J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC64970/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11752447/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.261581498
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