Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK

Granzyme B (GzmB) is a serine protease that is used by activated cytotoxic T lymphocytes to induce target cell apoptosis. Although GzmB directly cleaves the Bcl2 family member BID on target cell entry, Bid-deficient (and Bax, Bak doubly deficient) cells are susceptible to GzmB-induced death, even th...

תיאור מלא

מידע ביבליוגרפי

הוצא לאור ב:	Proc Natl Acad Sci U S A
Principais autores:	Thomas, Dori A., Scorrano, Luca, Putcha, Girish V., Korsmeyer, Stanley J., Ley, Timothy J.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	National Academy of Sciences 2001
נושאים:	Biological Sciences
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC64970/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11752447/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.261581498
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!