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PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice
Acute promyelocytic leukemia (APL) is characterized by the t(15;17) translocation that generates the fusion protein promyelocytic leukemia–retinoic acid receptor α (PML-RARA) in nearly all cases. Multiple prior mouse models of APL constitutively express PML-RARA from a variety of non-Pml loci. Typic...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3068978/ https://ncbi.nlm.nih.gov/pubmed/21364283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42953 |
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