PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice

Acute promyelocytic leukemia (APL) is characterized by the t(15;17) translocation that generates the fusion protein promyelocytic leukemia–retinoic acid receptor α (PML-RARA) in nearly all cases. Multiple prior mouse models of APL constitutively express PML-RARA from a variety of non-Pml loci. Typic...

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Main Authors: Welch, John S., Yuan, Wenlin, Ley, Timothy J.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2011
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068978/
https://ncbi.nlm.nih.gov/pubmed/21364283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42953
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