Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia

Acute promyelocytic leukemia (APL) is a hematological malignancy driven by a chimeric oncoprotein containing the C terminus of the retinoic acid receptor-a (RARa) fused to an N-terminal partner, most commonly promyelocytic leukemia protein (PML). Mechanistically, PML-RARa acts as a transcriptional r...

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Detalhes bibliográficos
Main Authors: dos Santos, Guilherme Augusto, Kats, Lev, Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865469/
https://ncbi.nlm.nih.gov/pubmed/24344243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131121
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