Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation

Acute promyelocytic leukemia is an aggressive malignancy characterized by the accumulation of promyelocytes in the bone marrow. PML/RARA is the primary abnormality implicated in this pathology, but the mechanisms by which this chimeric fusion protein initiates disease are incompletely understood. Id...

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Publicat a:Haematologica
Autors principals: Gaillard, Coline, Tokuyasu, Taku A., Rosen, Galit, Sotzen, Jason, Vitaliano-Prunier, Adeline, Roy, Ritu, Passegué, Emmanuelle, de Thé, Hugues, Figueroa, Maria E., Kogan, Scott C.
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004423/
https://ncbi.nlm.nih.gov/pubmed/26088929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2014.123018
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