Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

Por Pham, Christine T. N., Ley, Timothy J.
Publicado em 1999

Neutrophil Elastase Is Important for PML-Retinoic Acid Receptor α Activities in Early Myeloid Cells

Por Lane, Andrew A., Ley, Timothy J.
Publicado em 2005

PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice

Por Welch, John S., Yuan, Wenlin, Ley, Timothy J.
Publicado em 2011

YB-1 Is Important for Late-Stage Embryonic Development, Optimal Cellular Stress Responses, and the Prevention of Premature Senescence

Por Lu, Zhi Hong, Books, Jason T., Ley, Timothy J.
Publicado em 2005

Cold Shock Domain Family Members YB-1 and MSY4 Share Essential Functions during Murine Embryogenesis

Por Lu, Zhi Hong, Books, Jason T., Ley, Timothy J.
Publicado em 2006

Genomic Landscapes and Clonality of De Novo AML

Por Miller, Christopher A., Wilson, Richard K., Ley, Timothy J.
Publicado no N Engl J Med (2013)

Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice

Por Welch, John S., Klco, Jeffery M., Varghese, Nobish, Nagarajan, Rakesh, Ley, Timothy J.
Publicado em 2011

Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro

Por Sarkaria, Shawn M., Christopher, Matthew J., Klco, Jeffery M., Ley, Timothy J.
Publicado no Leukemia (2014)

Granzyme B is not required for regulatory T cell–mediated suppression of graft-versus-host disease

Por Cai, Sheng F., Cao, Xuefang, Hassan, Anjum, Fehniger, Todd A., Ley, Timothy J.
Publicado em 2010

Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice

Por Zimonjic, Drazen B., Pollock, Jessica L., Westervelt, Peter, Popescu, Nicholas C., Ley, Timothy J.
Publicado em 2000

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK

Por Thomas, Dori A., Scorrano, Luca, Putcha, Girish V., Korsmeyer, Stanley J., Ley, Timothy J.
Publicado em 2001

Granzymes and Caspase 3 Play Important Roles in Control of Gammaherpesvirus Latency

Por Loh, Joy, Thomas, Dori A., Revell, Paula A., Ley, Timothy J., Virgin, Herbert W.
Publicado em 2004

DNMT3A(R882)-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3A(R882C) OCI-AML3 leukemia cell line

Por Chen, David, Christopher, Matthew, Helton, Nichole M., Ferguson, Ian, Ley, Timothy J., Spencer, David H.
Publicado no Blood Cancer J (2018)

Long-range disruption of gene expression by a selectable marker cassette

Por Pham, Christine T. N., MacIvor, Debra M., Hug, Bruce A., Heusel, Jonathan W., Ley, Timothy J.
Publicado em 1996

Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia

Por Chang, Li Wei, Payton, Jacqueline E, Yuan, Wenlin, Ley, Timothy J, Nagarajan, Rakesh, Stormo, Gary D
Publicado em 2008

A bcr-3 isoform of RARα-PML potentiates the development of PML-RARα-driven acute promyelocytic leukemia

Por Pollock, Jessica L., Westervelt, Peter, Kurichety, Arun K., Pelicci, Pier Giuseppe, Grisolano, Jay L., Ley, Timothy J.
Publicado em 1999

Expression of a bcr-1 isoform of RARα-PML does not affect the penetrance of acute promyelocytic leukemia or the acquisition of an interstitial deletion on mouse chromosome 2

Por Walter, Matthew J., Ries, Rhonda E., Armstrong, Jon R., Park, John S., Mardis, Elaine R., Ley, Timothy J.
Publicado em 2007

POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature

Por Fortier, Julie M., Payton, Jacqueline E., Cahan, Patrick, Ley, Timothy J., Walter, Matthew J., Graubert, Timothy A.
Publicado em 2010

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia

Por Xiang, Zhifu, Luo, Hui, Payton, Jacqueline E., Cain, Jennifer, Ley, Timothy J., Opferman, Joseph T., Tomasson, Michael H.
Publicado em 2010

A protease-resistant PML-RARα has increased leukemogenic potential in a murine model of acute promyelocytic leukemia

Por Uy, Geoffrey L., Lane, Andrew A., Welch, John S., Grieselhuber, Nicole R., Payton, Jacqueline E., Ley, Timothy J.
Publicado em 2010