Alterations to the remote control of Shh gene expression cause congenital abnormalities

por Hill, Robert E., Lettice, Laura A.
Publicado 2013

Sonic hedgehog: restricted expression and limb dysmorphologies

por Hill, Robert E, Heaney, Simon JH, Lettice, Laura A
Publicado 2003

Mapping the Shh long-range regulatory domain

por Anderson, Eve, Devenney, Paul S., Hill, Robert E., Lettice, Laura A.
Publicado 2014

Shh and ZRS enhancer colocalisation is specific to the zone of polarising activity

por Williamson, Iain, Lettice, Laura A., Hill, Robert E., Bickmore, Wendy A.
Publicado en Development (2016)

The Conserved Sonic Hedgehog Limb Enhancer Consists of Discrete Functional Elements that Regulate Precise Spatial Expression

por Lettice, Laura A., Devenney, Paul, De Angelis, Carlo, Hill, Robert E.
Publicado en Cell Rep (2017)

Development of five digits is controlled by a bipartite long-range cis-regulator

por Lettice, Laura A., Williamson, Iain, Devenney, Paul S., Kilanowski, Fiona, Dorin, Julia, Hill, Robert E.
Publicado 2014

SBE6: a novel long-range enhancer involved in driving sonic hedgehog expression in neural progenitor cells

por Benabdallah, Nezha S., Gautier, Philippe, Hekimoglu-Balkan, Betul, Lettice, Laura A., Bhatia, Shipra, Bickmore, Wendy A.
Publicado en Open Biol (2016)

The mouse bagpipe gene controls development of axial skeleton, skull, and spleen

por Lettice, Laura A., Purdie, Lorna A., Carlson, Geoffrey J., Kilanowski, Fiona, Dorin, Julia, Hill, Robert E.
Publicado 1999

Cohesin is required for long-range enhancer action at the Shh locus

por Kane, Lauren, Williamson, Iain, Flyamer, Ilya M., Kumar, Yatendra, Hill, Robert E., Lettice, Laura A., Bickmore, Wendy A.
Publicado en Nat Struct Mol Biol (2022)

A variant in the sonic hedgehog regulatory sequence (ZRS) is associated with triphalangeal thumb and deregulates expression in the developing limb

por Furniss, Dominic, Lettice, Laura A., Taylor, Indira B., Critchley, Paul S., Giele, Henk, Hill, Robert E., Wilkie, Andrew O.M.
Publicado 2008

Anterior-posterior differences in HoxD chromatin topology in limb development

por Williamson, Iain, Eskeland, Ragnhild, Lettice, Laura A., Hill, Alison E., Boyle, Shelagh, Grimes, Graeme R., Hill, Robert E., Bickmore, Wendy A.
Publicado 2012

Developmentally regulated Shh expression is robust to TAD perturbations

por Williamson, Iain, Kane, Lauren, Devenney, Paul S., Flyamer, Ilya M., Anderson, Eve, Kilanowski, Fiona, Hill, Robert E., Bickmore, Wendy A., Lettice, Laura A.
Publicado en Development (2019)

Opposing Functions of the ETS Factor Family Define Shh Spatial Expression in Limb Buds and Underlie Polydactyly

por Lettice, Laura A., Williamson, Iain, Wiltshire, John H., Peluso, Silvia, Devenney, Paul S., Hill, Alison E., Essafi, Abdelkader, Hagman, James, Mort, Richard, Grimes, Graeme, DeAngelis, Carlo L., Hill, Robert E.
Publicado 2012

A Highly Conserved Shh Enhancer Coordinates Hypothalamic and Craniofacial Development

por Crane-Smith, Zoe, Schoenebeck, Jeffrey, Graham, Katy A., Devenney, Paul S., Rose, Lorraine, Ditzell, Mark, Anderson, Eve, Thomson, Joseph I., Klenin, Natasha, Kurrasch, Deborah M., Lettice, Laura A., Hill, Robert E.
Publicado en Front Cell Dev Biol (2021)

Deletion of CTCF sites in the SHH locus alters enhancer–promoter interactions and leads to acheiropodia

por Ushiki, Aki, Zhang, Yichi, Xiong, Chenling, Zhao, Jingjing, Georgakopoulos-Soares, Ilias, Kane, Lauren, Jamieson, Kirsty, Bamshad, Michael J., Nickerson, Deborah A., Shen, Yin, Lettice, Laura A., Silveira-Lucas, Elizabeth Lemos, Petit, Florence, Ahituv, Nadav
Publicado en Nat Commun (2021)

Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin

por Martínez-Estrada, Ofelia M., Lettice, Laura A., Essafi, Abdelkader, Guadix, Juan Antonio, Slight, Joan, Velecela, Victor, Hall, Emma, Reichmann, Judith, Devenney, Paul S., Hohenstein, Peter, Hosen, Naoki, Hill, Robert E., Muñoz-Chapuli, Ramón, Hastie, Nicholas D.
Publicado 2009

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

por Reijns, Martin A.M., Rabe, Björn, Rigby, Rachel E., Mill, Pleasantine, Astell, Katy R., Lettice, Laura A., Boyle, Shelagh, Leitch, Andrea, Keighren, Margaret, Kilanowski, Fiona, Devenney, Paul S., Sexton, David, Grimes, Graeme, Holt, Ian J., Hill, Robert E., Taylor, Martin S., Lawson, Kirstie A., Dorin, Julia R., Jackson, Andrew P.
Publicado 2012

Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly

por Lettice, Laura A., Horikoshi, Taizo, Heaney, Simon J. H., van Baren, Marijke J., van der Linde, Herma C., Breedveld, Guido J., Joosse, Marijke, Akarsu, Nurten, Oostra, Ben A., Endo, Naoto, Shibata, Minoru, Suzuki, Mikio, Takahashi, Eiichi, Shinka, Toshikatsu, Nakahori, Yutaka, Ayusawa, Dai, Nakabayashi, Kazuhiko, Scherer, Stephen W., Heutink, Peter, Hill, Robert E., Noji, Sumihare
Publicado 2002