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Cohesin is required for long-range enhancer action at the Shh locus
The regulatory landscapes of developmental genes in mammals can be complex, with enhancers spread over many hundreds of kilobases. It has been suggested that three-dimensional genome organisation, particularly topologically associating domains formed by cohesin-mediated loop extrusion, are important...
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| Veröffentlicht in: | Nat Struct Mol Biol |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2022
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7613721/ https://ncbi.nlm.nih.gov/pubmed/36097291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-022-00821-8 |
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