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Developmentally regulated Shh expression is robust to TAD perturbations
Topologically Associating Domains (TADs) have been proposed to both guide and constrain enhancer activity. Shh is located within a TAD known to contain all its enhancers. To investigate the importance of chromatin conformation and TAD integrity on developmental gene regulation, we have manipulated t...
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| 出版年: | Development |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7212092/ https://ncbi.nlm.nih.gov/pubmed/31511252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.179523 |
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