Загрузка...

Cohesin is required for long-range enhancer action at the Shh locus

The regulatory landscapes of developmental genes in mammals can be complex, with enhancers spread over many hundreds of kilobases. It has been suggested that three-dimensional genome organisation, particularly topologically associating domains formed by cohesin-mediated loop extrusion, are important...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Nat Struct Mol Biol
Главные авторы: Kane, Lauren, Williamson, Iain, Flyamer, Ilya M., Kumar, Yatendra, Hill, Robert E., Lettice, Laura A., Bickmore, Wendy A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2022
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613721/
https://ncbi.nlm.nih.gov/pubmed/36097291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-022-00821-8
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!