Opposing Functions of the ETS Factor Family Define Shh Spatial Expression in Limb Buds and Underlie Polydactyly

Sonic hedgehog (Shh) expression during limb development is crucial for specifying the identity and number of digits. The spatial pattern of Shh expression is restricted to a region called the zone of polarizing activity (ZPA), and this expression is controlled from a long distance by the cis-regulat...

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Bibliografiske detaljer
Main Authors: Lettice, Laura A., Williamson, Iain, Wiltshire, John H., Peluso, Silvia, Devenney, Paul S., Hill, Alison E., Essafi, Abdelkader, Hagman, James, Mort, Richard, Grimes, Graeme, DeAngelis, Carlo L., Hill, Robert E.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2012
Fag:
Short Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314984/
https://ncbi.nlm.nih.gov/pubmed/22340503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.12.010
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