Unraveling Viral Interleukin-6 Binding to gp130 and Activation of STAT-Signaling Pathways Independently of the Interleukin-6 Receptor

Por Adam, Nina, Rabe, Björn, Suthaus, Jan, Grötzinger, Joachim, Rose-John, Stefan, Scheller, Jürgen
Publicado em 2009

Temperate Streptococcus thermophilus phages expressing superinfection exclusion proteins of the Ltp type

Por Ali, Yahya, Koberg, Sabrina, Heßner, Stefanie, Sun, Xingmin, Rabe, Björn, Back, Angela, Neve, Horst, Heller, Knut J.
Publicado em 2014

Abrogation of Viral Interleukin-6 (vIL-6)-Induced Signaling by Intracellular Retention and Neutralization of vIL-6 with an Anti-vIL-6 Single-Chain Antibody Selected by Phage Displa...

Por Kovaleva, Marina, Bussmeyer, Ingo, Rabe, Björn, Grötzinger, Joachim, Sudarman, Enge, Eichler, Jutta, Conrad, Udo, Rose-John, Stefan, Scheller, Jürgen
Publicado em 2006

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17

Por Riethmueller, Steffen, Ehlers, Johanna C., Lokau, Juliane, Düsterhöft, Stefan, Knittler, Katharina, Dombrowsky, Gregor, Grötzinger, Joachim, Rabe, Björn, Rose-John, Stefan, Garbers, Christoph
Publicado no Sci Rep (2016)

Human and Murine Interleukin 23 Receptors Are Novel Substrates for A Disintegrin and Metalloproteases ADAM10 and ADAM17

Por Franke, Manuel, Schröder, Jutta, Monhasery, Niloufar, Ackfeld, Theresa, Hummel, Thorben M., Rabe, Björn, Garbers, Christoph, Becker-Pauly, Christoph, Floss, Doreen M., Scheller, Jürgen
Publicado no J Biol Chem (2016)

The Amino Acid Exchange R28E in Ciliary Neurotrophic Factor (CNTF) Abrogates Interleukin-6 Receptor-dependent but Retains CNTF Receptor-dependent Signaling via Glycoprotein 130 (gp...

Por Wagener, Eva-Maria, Aurich, Matthias, Aparicio-Siegmund, Samadhi, Floss, Doreen M., Garbers, Christoph, Breusing, Kati, Rabe, Björn, Schwanbeck, Ralf, Grötzinger, Joachim, Rose-John, Stefan, Scheller, Jürgen
Publicado em 2014

Polo-like Kinase 2, a Novel ADAM17 Signaling Component, Regulates Tumor Necrosis Factor α Ectodomain Shedding

Por Schwarz, Jeanette, Schmidt, Stefanie, Will, Olga, Koudelka, Tomas, Köhler, Kaja, Boss, Melanie, Rabe, Björn, Tholey, Andreas, Scheller, Jürgen, Schmidt-Arras, Dirk, Schwake, Michael, Rose-John, Stefan, Chalaris, Athena
Publicado em 2014

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling

Por Arnold, Philipp, Boll, Inga, Rothaug, Michelle, Schumacher, Neele, Schmidt, Frederike, Wichert, Rielana, Schneppenheim, Janna, Lokau, Juliane, Pickhinke, Ute, Koudelka, Tomas, Tholey, Andreas, Rabe, Björn, Scheller, Jürgen, Lucius, Ralph, Garbers, Christoph, Rose-John, Stefan, Becker-Pauly, Christoph
Publicado no Sci Rep (2017)

The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth

Por Nivarthi, Harini, Gordziel, Claire, Themanns, Madeleine, Kramer, Nina, Eberl, Markus, Rabe, Björn, Schlederer, Michaela, Rose-John, Stefan, Knösel, Thomas, Kenner, Lukas, Freund, Patricia, Aberger, Fritz, Han, Xiaonan, Kralovics, Robert, Dolznig, Helmut, Jennek, Susanne, Friedrich, Karlheinz, Moriggl, Richard
Publicado no Oncotarget (2016)

Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating...

Por Schumacher, Neele, Meyer, Dörte, Mauermann, Andre, von der Heyde, Jan, Wolf, Janina, Schwarz, Jeanette, Knittler, Katharina, Murphy, Gillian, Michalek, Matthias, Garbers, Christoph, Bartsch, Jörg W., Guo, Songbo, Schacher, Beate, Eickholz, Peter, Chalaris, Athena, Rose-John, Stefan, Rabe, Björn
Publicado no J Biol Chem (2015)

Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response

Por Mackenzie, Karen J, Carroll, Paula, Lettice, Laura, Tarnauskaitė, Žygimantė, Reddy, Kaalak, Dix, Flora, Revuelta, Ailsa, Abbondati, Erika, Rigby, Rachel E, Rabe, Björn, Kilanowski, Fiona, Grimes, Graeme, Fluteau, Adeline, Devenney, Paul S, Hill, Robert E, Reijns, Martin AM, Jackson, Andrew P
Publicado no EMBO J (2016)

IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality

Por Zhang, Hong, Neuhöfer, Patrick, Song, Liang, Rabe, Björn, Lesina, Marina, Kurkowski, Magdalena U., Treiber, Matthias, Wartmann, Thomas, Regnér, Sara, Thorlacius, Henrik, Saur, Dieter, Weirich, Gregor, Yoshimura, Akihiko, Halangk, Walter, Mizgerd, Joseph P., Schmid, Roland M., Rose-John, Stefan, Algül, Hana
Publicado em 2013

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

Por Reijns, Martin A.M., Rabe, Björn, Rigby, Rachel E., Mill, Pleasantine, Astell, Katy R., Lettice, Laura A., Boyle, Shelagh, Leitch, Andrea, Keighren, Margaret, Kilanowski, Fiona, Devenney, Paul S., Sexton, David, Grimes, Graeme, Holt, Ian J., Hill, Robert E., Taylor, Martin S., Lawson, Kirstie A., Dorin, Julia R., Jackson, Andrew P.
Publicado em 2012