The Amino Acid Exchange R28E in Ciliary Neurotrophic Factor (CNTF) Abrogates Interleukin-6 Receptor-dependent but Retains CNTF Receptor-dependent Signaling via Glycoprotein 130 (gp130)/Leukemia Inhibitory Factor Receptor (LIFR)

Ciliary neurotrophic factor (CNTF) is a neurotrophic factor with therapeutic potential for neurodegenerative diseases. Moreover, therapeutic application of CNTF reduced body weight in mice and humans. CNTF binds to high or low affinity receptor complexes consisting of CNTFR·gp130·LIFR or IL-6R·gp130...

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Bibliographic Details
Main Authors: Wagener, Eva-Maria, Aurich, Matthias, Aparicio-Siegmund, Samadhi, Floss, Doreen M., Garbers, Christoph, Breusing, Kati, Rabe, Björn, Schwanbeck, Ralf, Grötzinger, Joachim, Rose-John, Stefan, Scheller, Jürgen
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140248/
https://ncbi.nlm.nih.gov/pubmed/24802752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568857
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