Abrogation of Viral Interleukin-6 (vIL-6)-Induced Signaling by Intracellular Retention and Neutralization of vIL-6 with an Anti-vIL-6 Single-Chain Antibody Selected by Phage Display

Human herpesvirus 8 (HHV-8) encodes several putative oncogenes, which are homologues to cellular host genes known to function in cell cycle regulation, control of apoptosis, and cytokine signaling. Viral interleukin (vIL-6) is believed to play an important role in the pathogenesis of Kaposi's s...

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Hlavní autoři: Kovaleva, Marina, Bussmeyer, Ingo, Rabe, Björn, Grötzinger, Joachim, Sudarman, Enge, Eichler, Jutta, Conrad, Udo, Rose-John, Stefan, Scheller, Jürgen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
Cellular Response to Infection
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563863/
https://ncbi.nlm.nih.gov/pubmed/16912301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00420-06
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