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Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response
Aicardi–Goutières syndrome (AGS) provides a monogenic model of nucleic acid‐mediated inflammation relevant to the pathogenesis of systemic autoimmunity. Mutations that impair ribonuclease (RNase) H2 enzyme function are the most frequent cause of this autoinflammatory disorder of childhood and are al...
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| Publicado en: | EMBO J |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4855687/ https://ncbi.nlm.nih.gov/pubmed/26903602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593339 |
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