Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response

Aicardi–Goutières syndrome (AGS) provides a monogenic model of nucleic acid‐mediated inflammation relevant to the pathogenesis of systemic autoimmunity. Mutations that impair ribonuclease (RNase) H2 enzyme function are the most frequent cause of this autoinflammatory disorder of childhood and are al...

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Publicado en:EMBO J
Main Authors: Mackenzie, Karen J, Carroll, Paula, Lettice, Laura, Tarnauskaitė, Žygimantė, Reddy, Kaalak, Dix, Flora, Revuelta, Ailsa, Abbondati, Erika, Rigby, Rachel E, Rabe, Björn, Kilanowski, Fiona, Grimes, Graeme, Fluteau, Adeline, Devenney, Paul S, Hill, Robert E, Reijns, Martin AM, Jackson, Andrew P
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855687/
https://ncbi.nlm.nih.gov/pubmed/26903602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593339
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