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The cGAS-STING pathway for DNA sensing

The nucleotidyl transferase cGAS, its second messenger product cGAMP and the cGAMP sensor STING, form the basic mechanism of DNA sensing in the cytoplasm of mammalian cells. Several new reports now uncover key structural features associated with DNA recognition by cGAS and the catalytic mechanisms o...

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Detalles Bibliográficos
Autores principales: Xiao, T. Sam, Fitzgerald, Katherine A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782533/
https://ncbi.nlm.nih.gov/pubmed/23870141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.07.004
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