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The cGAS-STING pathway for DNA sensing
The nucleotidyl transferase cGAS, its second messenger product cGAMP and the cGAMP sensor STING, form the basic mechanism of DNA sensing in the cytoplasm of mammalian cells. Several new reports now uncover key structural features associated with DNA recognition by cGAS and the catalytic mechanisms o...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3782533/ https://ncbi.nlm.nih.gov/pubmed/23870141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.07.004 |
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