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The cGAS-STING pathway for DNA sensing

The nucleotidyl transferase cGAS, its second messenger product cGAMP and the cGAMP sensor STING, form the basic mechanism of DNA sensing in the cytoplasm of mammalian cells. Several new reports now uncover key structural features associated with DNA recognition by cGAS and the catalytic mechanisms o...

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Detalhes bibliográficos
Main Authors: Xiao, T. Sam, Fitzgerald, Katherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782533/
https://ncbi.nlm.nih.gov/pubmed/23870141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.07.004
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