Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses

Infection of cells with DNA viruses triggers innate immune responses mediated by DNA sensors. cGMP-AMP synthase (cGAS) is a key DNA sensor that produces the cyclic dinucleotide cGMP-AMP (cGAMP) upon activation, which binds to and activates stimulator of interferon genes (STING), leading to IFN produ...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ma, Zhe, Jacobs, Sarah R., West, John A., Stopford, Charles, Zhang, Zhigang, Davis, Zoe, Barber, Glen N., Glaunsinger, Britt A., Dittmer, Dirk P., Damania, Blossom
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534226/
https://ncbi.nlm.nih.gov/pubmed/26199418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503831112
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