Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses

Infection of cells with DNA viruses triggers innate immune responses mediated by DNA sensors. cGMP-AMP synthase (cGAS) is a key DNA sensor that produces the cyclic dinucleotide cGMP-AMP (cGAMP) upon activation, which binds to and activates stimulator of interferon genes (STING), leading to IFN produ...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Ma, Zhe, Jacobs, Sarah R., West, John A., Stopford, Charles, Zhang, Zhigang, Davis, Zoe, Barber, Glen N., Glaunsinger, Britt A., Dittmer, Dirk P., Damania, Blossom
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2015
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534226/
https://ncbi.nlm.nih.gov/pubmed/26199418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503831112
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk