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The cytosolic DNA-sensing cGAS-STING pathway in cancer

The recognition of DNA as an immune stimulatory molecule is an evolutionarily conserved mechanism to initiate rapid innate immune response against microbial pathogens. Recently, the cGAS-STING pathway has been discovered as an important DNA sensing machinery in innate immunity and viral defense. Rec...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Discov
Hauptverfasser: Kwon, John, Bakhoum, Samuel F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7151642/
https://ncbi.nlm.nih.gov/pubmed/31852718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0761
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