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cGAS–STING cytosolic DNA sensing pathway is suppressed by JAK2-STAT3 in tumor cells
Deficiencies in DNA repair and DNA degrading nucleases lead to accumulation of cytosolic DNA. cGAS is a critical DNA sensor for the detection of cytosolic DNA and subsequent activation of the STING signaling pathway. Here, we show that the cGAS-STING pathway was unresponsive to STING agonists and fa...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8012641/ https://ncbi.nlm.nih.gov/pubmed/33790360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86644-x |
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