Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING

Cyclic GMP-AMP (cGAMP) synthase (cGAS) is recently identified as a cytosolic DNA sensor and generates a non-canonical cGAMP that contains G(2′,5′)pA and A(3′,5′)pG phosphodiester linkages. cGAMP activates STING which triggers innate immune responses in mammals. However, the evolutionary functions an...

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Bibliografiske detaljer
Main Authors: Wu, Xiaomei, Wu, Fei-Hua, Wang, Xiaoqiang, Wang, Lilin, Siedow, James N., Zhang, Weiguo, Pei, Zhen-Ming
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Computational Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117786/
https://ncbi.nlm.nih.gov/pubmed/24981511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku569
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