Cytosolic RNA:DNA hybrids activate the cGAS–STING axis

Intracellular recognition of non-self and also self-nucleic acids can result in the initiation of potent pro-inflammatory and antiviral cytokine responses. Most recently, cGAS was shown to be critical for the recognition of cytoplasmic dsDNA. Binding of dsDNA to cGAS results in the synthesis of cGAM...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:EMBO J
Main Authors: Mankan, Arun K, Schmidt, Tobias, Chauhan, Dhruv, Goldeck, Marion, Höning, Klara, Gaidt, Moritz, Kubarenko, Andrew V, Andreeva, Liudmila, Hopfner, Karl-Peter, Hornung, Veit
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2014
Assuntos:
Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282641/
https://ncbi.nlm.nih.gov/pubmed/25425575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488726
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares