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Structural mechanism of cytosolic DNA sensing by cGAS
Cytosolic DNA arising from intracellular bacteria or viral infections is a powerful pathogen-associated molecular pattern (PAMP) that leads to innate immune host defense by the production of type I interferon and inflammatory cytokines. Recognition of cytosolic DNA by the recently discovered cyclic-...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3768140/ https://ncbi.nlm.nih.gov/pubmed/23722159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12305 |
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